TITLE:
Changes in Plasma Levels of Vasoactive Factors in Patients Undergoing Abdominal Surgery
AUTHORS:
Jinwen Zhang, Meng Li, Feng Zhang
KEYWORDS:
Prostacyclin, Endothelin, Thromboxane A2, Nitric Oxide, Deep Venous Thrombosis, Thrombotic State
JOURNAL NAME:
Surgical Science,
Vol.5 No.9,
September
29,
2014
ABSTRACT: Background: To
investigate the changes in plasma levels of endothelin (ET), nitric oxide (NO),
prostacyclin (PGI2) and thromboxane A2 (TXA2)
in patients undergoing abdominal operation. Materials and Methods: Thirty cases
of abdominal surgery (14 males, 16 females; mean age 48 ± 11 years, ranging
from 24 to 70) were prospectively recruited: Twenty-four cases of
cholelithiasis and cholecystitis, 2 cases of peptic ulcer and 4 cases of portal
vein hypertension. At five different time points (1-3 days after
hospitalization (T1), at surgery beginning, after anesthesia (T2) and at the
first (T3), third (T4) and fifth day (T5) after surgery), plasma levels of
ET-1, NO2-, NO3-,6-keto-PGF1α and thromboxane B2 (TXB2), the latter
two being stable metabolites of PGI2 and TXA2 respectively, were measured. Results: ET-1 levels increased significantly after
anesthesia and surgery (T1 = 69.2 ± 10.7 vs. T2 = 82.4 ± 14.7 vs. T3 = 96.6 ± 22.8
pg/ml, p 2 levels before surgery were significantly
lower than that after (T2 = 67.5 ± 52.7 vs. T3 = 157.6 ± 21.8 pg/ml, p 1α were significantly higher than that after anesthesia and surgery (T1 = 180.5 ± 17.8
vs. T2 = 132.1 ± 32.6 vs. T3 = 110.9 ± 31.9 pg/ml, p 2)
increased significantly after surgery, while vasodilatory factors (NO and PGI2)
decreased significantly after operation. Imbalance in vasoactive factors encourages
hypercoagulability and then may play a role in the pathobiology of post-surgery
complications, such as deep venous thrombosis (DVT).