TITLE:
The Effect of Percutaneous Coronary Intervention on Left Ventricular Diastolic Dysfunction in Patients with Coronary Artery Disease Assessed by Strain Rate Imaging
AUTHORS:
Fariba Bayat, Elham Farahani, Habibollah Saadat
KEYWORDS:
Strain Rate, Percutaneous Coronary Intervention, Diastolic Function
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.4 No.10,
September
25,
2014
ABSTRACT: Introduction: Coronary
artery disease (CAD) is the most common cause for left ventricular dysfunction.
Unfortunately, the treatment strategies of regional myocardial diastolic
dysfunction in patients with CAD have not been well characterized and benefit
of percutaneous coronary intervention (PCI) as a treatment strategy is not
clear. So the present study aimed to assess the effects of PCI on regional and global left ventricular diastolic dysfunction in patients
with CAD assessed by strain rate (SR) imaging. Methods: Thirty adult symptomatic
patients with coronary artery disease that underwent coronary angiography and
candidate for PCI on left anterior descending artery were enrolled to our
study. Echocardiographic findings and early diastolic SR were measured before
and 48 hours after PCI. Results: Mean age of the patients was 59.9 ± 8.3 years.
Most of the left ventricular diastolic
parameters showed significant difference before and after elective PCI; while
mitral E velocity, DT, E/A and pulmonary vein flow before and after PCI did not
show significant difference assessed by statically test. Also before PCI, mean
(SD) of peak early diastolic SR in ischemic regions (1.89 ± 0.22) was smaller than of non-ischemic regions (2.53 ± 0.26)
while after PCI this parameter became similar in ischemic
regions (2.55 ± 0.27) and non-ischemic
regions (2.55 ± 0.26). Conclusion: Most of
the left ventricular diastolic parameters improved after PCI in CAD patients.
Also regional myocardial relaxation as measured by peak early diastolic SR (ESR) in the ischemic segments
improved significantly compared with that in non-ischemic segments.