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Rosales-Corral, S.A. Acuña-Castroviejo, D., Coto-Montes, A., Boga, J.A., Manchester, L.C., Fuentes-Broto, L., Korkmaz, A., Ma, S., Tan, D.X. and Reiter, R.J. (2012) Alzheimer’s Disease: Pathological Mechanisms and the Beneficial Role of Melatonin. Journal of Pineal Research, 52, 167-202.
http://dx.doi.org/10.1111/j.1600-079X.2011.00937.x

has been cited by the following article:

• TITLE: Melatonin Avoids Anatomofunctional Changes Associated to Aging in a Rat Model

  AUTHORS: Bertha Prieto Gómez, Cruz Reyes-Vázquez, Mireya Velázquez-Paniagua

  KEYWORDS: Rat, Melatonin, Hippocampus, Antioxidant, Aging

  JOURNAL NAME: Advances in Aging Research, Vol.3 No.4, September 18, 2014

  ABSTRACT: Melatonin is a hormone synthesized and released primarily by the pineal gland. Its secretion fol-lows a circadian rhythm with a peak overnight. Its secretion is initiated approximately to the three months of age and continues to rise during the childhood. Previous to the puberty there is a de-crease of melatonin secretion that continues until the old age. Melatonin has effects in the body and acts through at least four mechanisms: membrane receptors, orphan nuclear receptors, calmodulin and free radicals. It has been suggested that aging can be a consequence of the oxidation of cells that eventually become vulnerable to injury and die. This work reviews the antioxidant effects of melatonin in a rodent model, on the formation of free radicals, on the MAP2 protein expression and on the electrophysiology of the hippocampus at different ages. The results indicate that melatonin maintains in a “best” state to the experimental animals compared to controls. It suggests the use of melatonin as a therapy to prevent or delay the aging effects on the cells.