TITLE:
Schistosomiasis and Urothelial Bladder Carcinoma
AUTHORS:
Rodrigo de Carvalho Holanda Leite, Cecília Maria de Carvalho Xavier Holanda, Paulo José de Medeiros
KEYWORDS:
Schistosoma mansoni, Bladder Cancer, Schistosomiasis, Oxamniquine
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.3 No.9,
September
18,
2014
ABSTRACT: Bladder cancer is the
most common malignancy of the urinary tract and it affects four times
more men than women. The relationship between bladder tumors and Schistosoma
haematobium is well known, but only sporadic cases of bladder infection due
to Schistosoma mansoni have been reported. Schistosoma mansoni infection causes an endemic disease in Brazil (schistosomiasis)
and gastrointestinal disorders are very common, but disease of the urinary
tract is atypical. The aim of this study was to describe a case
of a patient presenting schistosomiasis (S.
mansoni) and urothelial bladder carcinoma. In this case, a 37-year-old man with
intermittent painless gross hematuria was investigated. Cystoscopy revealed a small
pedunculated lesion in the bladder dome. Transurethral resection revealed
urothelial carcinoma of the bladder, low degree, unrepresentative of the
muscular layer of the bladder. After 30 days, a new transurethral resection was
performed to sample acquisition of the muscular layer on the basis of the scar.
Histopathology was negative for malignancy (Tumor Node Metastasis: TNM-T1).
During this procedure, there was evidence of dark rounded lesion in the bladder
dome. It was excised and the histopathology showed viable eggs of Schistosoma
mansoni. The patient was treated orally with oxamniquine and remained in
oncological monitoring with cystoscopy quarterly and serial clinical
evaluation. This case reveals a rare finding of Schistosoma mansoni in
the bladder and urothelial bladder carcinoma coexisting in the same patient.