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[19] Y. H. Cheng, A. Margaret Dyer, I. Jabbal-Gill, M. Hinch-cliffe, R. Nankervis, A. Smith and P. Watts, “Intranasal Delivery of Recombinant Human Growth Hormone (Somatropin) in Sheep Using Chitosan-Based Powder Formulations,” European Journal of Pharmaceutical Sci-ences, Vol. 26, No. 1, 2005, pp. 9-15. doi:10.1016/j.ejps.2005.03.014

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• TITLE: Preparation of biocompatible magnetic microspheres with chitosan

  AUTHORS: Mohamed K. Nasra, Moustafa M. Mohamed, Mohamed A. Elblbesy, Bothaina A. Hefney

  KEYWORDS: Magnetic, Microspheres, Chitosan

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.2 No.2, March 21, 2011

  ABSTRACT: Microsphere is a term used for small spherical particles, with diameters in the micrometer range (typically 1μm to 1000μm (1mm)). Microspheres are sometimes referred to as microparticles. Microspheres can be manufactured from various natural and synthetic materials. The present work we prepared chitosan magnetic microspheres (CMMS) with simple crosslinking method. The obtained CMMS were in size range of 1000-2600 nm with average particle size of 1800nm. All the essential characterizations of prepared CMMS were done and the results were in a good agreement with other magnetic microspheres prepared with different method. To test the biocompatibility of CMMS with blood, the effect of them on erythrocytes aggregation and blood hemolysis were studied. Our results showed that CMMS work as good compatible materials with blood.