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Singh, S.K., Hawkins, C., Clarke, I.D., Squire, J.A., Bayani, J., Hide, T., Henkelman, R.M., Cusimano, M.D. and Dirks, P.B. (2004) Identification of Human Brain Tumour Initiating Cells. Nature, 432, 396-401. http://dx.doi.org/10.1038/nature03128

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• TITLE: A Review on the Biology of Cancer Stem Cells

  AUTHORS: Mansouri Atena, Abbaszadegan Mohammad Reza, Gholamin Mehran

  KEYWORDS: Cancer, Stem Cells, CSC

  JOURNAL NAME: Stem Cell Discovery, Vol.4 No.4, September 16, 2014

  ABSTRACT: Cancer Stem Cells (CSC) have the ability to self-renew and are present in most tissues including breast, brain, lung, prostates, testis, ovary, esophagus, colon, and liver. Their origin is yet to be discovered, though a series of hypotheses have been proposed in this regard. CSCs play a role in not only the creation of cancer, but also in its evolution, metastasis, and recurrence. CSCs have an important role in cancer therapy and the resistance towards chemotherapeutic agents. This article reviews the characteristics of cancer stem cells in terms of origin, resistance towards chemotherapy, methods of isolation, and cancer therapy.