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Inoue, M., Okajima, K., Itoh, K., Ando, Y., Watanabe, N., Yasaka, T., Nagase, S. and Morino, Y. (1987) Mechanism of Furosemide Resistance in Analbuminemic Rats and Hypoalbuminemic Patients. Kidney International, 32, 198-203.
http://dx.doi.org/10.1038/ki.1987.192

has been cited by the following article:

• TITLE: Effectiveness of Bumetanide Infusion in Treatment of Generalized Edema and Congestive Heart Failure

  AUTHORS: Anil K. Mandal

  KEYWORDS: Bumetanide Infusion, Generalized Edema, Congestive Heart Failure

  JOURNAL NAME: Open Journal of Internal Medicine, Vol.4 No.3, September 10, 2014

  ABSTRACT: Generalized edema (anasarca) is common in nephrotic syndrome which rarely produces shortness of breath. Increased shortness of breath associated with rapid weight gain and generalized edema signify congestive heart failure (CHF). Loop diuretics consisting of furosemide (Lasix®), bumetanide (Bumex®), torsemide (Demadex®) or ethacrynic acid (Edecrin) are effective diuretics to treat anasarca. However, efficacy varies depending on the renal function. Loop diuretic given orally or by intravenous boluses produce good urine output but overall response in reducing edema or shortness of breath as in CHF is less than optimum. Although literature information is very limited, continuous bumetanide infusion for 72 to 96 hours is found to be very effective in producing subjective relief of shortness of breath as well as objective improvement such as reduction in brain natriuretic peptide in CHF and improved kidney function, so that diuresis is sustained even after discontinuation of the infusion. Decrease in kidney function and electrolytes and acid-base imbalance are common but they are reversible with prompt replacement therapy. They pose no threat to life.