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Kato, T., Okahashi, N., Kaeai, S., Kato, T., Inaba, H., Morisaki, I. and Amano, A. (2005) Impaired Degradation of Matrix Collagen in Human Gingival Fibroblast by the Antiepileptic Drug Phenytoin. Journal of Periodontology, 76, 941-950.
http://dx.doi.org/10.1902/jop.2005.76.6.941

has been cited by the following article:

• TITLE: Phenytoin Effects on Proliferation and Induction of IL1β and PGE2 in Pediatric and Adults’ Gingival Fibroblasts

  AUTHORS: Surena Vahabi, Masomeh Moslemi, Bahareh Nazemisalman, Zahra Yadegari

  KEYWORDS: Phenytoin, Gingival Overgrowth, Fibroblast, Interleukin, Children

  JOURNAL NAME: Open Journal of Stomatology, Vol.4 No.9, September 10, 2014

  ABSTRACT: Background: Gingival Overgrowth (GO) is a well documented and unwanted side effect that occurs mainly as a result of certain antiseizure, phenytoin. The aim of this study was to compare the effect of phenytoin on proliferation and production of IL1β and PGE2 in cultured human gingival fibroblasts (HGF) of children and adults. Materials and Methods: Normal HGFs were obtained from 4 healthy children and 4 adult and then were cultured with phenytoin (20 mg/ml). MTT test was used to evaluate the proliferation and ELISA to determine the level of IL1β and PGE2 production by HGFs. Analysis of proliferation were assessed by Independent T-Test and ANOVA analysis was used to assess the level of IL1β and PGE2 production with an a error level less than 0.05. Results: The proliferation of HGF was not affected significantly by phenytoin in both cultured fibroblast sources (P > 0.05). Phenytoin induced a significantly higher formation of IL1β and PGE2 in child’s HGFs as compared to adult’s HGFs (P