TITLE:
Improvement of Live Birth Rate Following Frozen-Thawed Blastocyst Transfer by Combination of Prednisolone Administration and Stimulation of Endometrium Embryo Transfer
AUTHORS:
Taketo Inoue, Yoshiyuki Ono, Yukiko Yonezawa, Junji Kishi, Nobuyuki Emi
KEYWORDS:
Frozen–Thawed Blastocyst Transfer, Infertility, Live Birth, Prednisolone, Stimulation of Endometrium Embryo Transfer (SEET)
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.4 No.13,
September
9,
2014
ABSTRACT: The endometrial condition
is a significant factor for successful pregnancy. To regulate endometrial
function in fertility treatment, prednisolone (PSL) is administered for suppression of increased natural killer cells and stimulation
of endometrium embryo transfer (SEET) to enhance communication between embryo
and maternal tissues. We attempted to improve the endometrial condition by PSL
administration and SEET during frozen–thawed blastocyst transfer (FBT).
Patients took PSL (5 mg) 3 times daily for 3 days after ovulation during the
FBT cycle. To analyse effects of PSL combined with SEET, we determined rates of
chemical pregnancy, clinical pregnancy, foetal heart movement (FHM) and live
birth. Rates of chemical pregnancy, clinical pregnancy and FHM were
significantly higher in the PSL(+)/SEET(+) (57.7%, 50.0% and 46.2%,
respectively) and PSL(+)/SEET(-)
(53.3%, 46.7% and 46.7%, respectively) groups than in the PSL(-)/SEET(+)
(30.3%, 18.2% and 18.2%, respectively) and PSL(-)/SEET(-) (22.4%, 22.4% and
18.4%; P = 0.0043, 0.0081 and 0.0055, respectively) groups. The
live birth rate was significantly higher in the PSL(+)/SEET(+) group than in the PSL(+)/SEET(-),
PSL(-)/SEET(+) and PSL(-)/SEET(-) groups (42.3%, 26.7%, 18.2% and 12.2%, respectively; P = 0.0237). PSL combined with SEET may
be a useful adjunct to assisted reproductive technology in women
who repeatedly fail to conceive by infertility treatment.