TITLE:
Antibiotic Resistance in Blood Culture Samples from Patients Referred to Razi Laboratory of Rasht, 2006-2011
AUTHORS:
Fatemeh Saeidynia, Faeze Keihanian, Amin Saeidynia
KEYWORDS:
Pattern of Resistance, Antibiotic, Rasht, North of Iran
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.4 No.3,
September
5,
2014
ABSTRACT: Introduction: Irregular wide antibiotic
administration by physicians and over the counter use of them had led to
inappropriate or non-essential choice of antibiotic. If blood related diseases
like sepsis and bacteremia, have not been diagnosed and treated as soon as
possible, they can make high complications and mortalities. This study was
conducted to survey of epidemiological changes about frequency of
micro-organisms in blood cultures in Razi laboratory of Rasht during 2006 to
2011. Material & Methods: This is a descriptive retrospective study
performed by information database of Razi laboratory. For all of positive
samples addressed for blood culture, anti-biograms had been done by method of
Kirby & Bauer and agar diffusion. Last, formation or deformation of growth
zone was evaluated and on the basis of standard table, results were classified
to three categories of sensitive, intermediate and resistance. All of common
standard antibiotic disks had been used in this survey. Results: In all cases
which addressed for culture (466 cases) 43 subjects (9.22%) were positive and
one of them was contaminated. The most frequent bacteria separated from the
blood cultures were respectively: coagulase negative Staphylococcus, Escherichia
coli, Pseudomonas aeruginosa, Klebsiella and coagulase positive Staphylococcus. Relation
between type of bacteria and gender of patients was significant (P = 0.001) in
which in female cases it was the most frequent. The most resistance in all of
applied antibiotics in coagulase negative Staphylococcus group was 60.2%, in gram
negative non non-fermentative bacillus group was 43.16% and in gram
negative intestinal bacteria group was 39.25%. Discussion & Conclusion:
Although there are similar results in the pattern of resistance in comparison
of other studies, pattern of this study is unique and exclussive for Rasht city
and it is based on hygienic condition of Guilan province. Because of being
respective and variables were not considerd by opinions of researchers of this
study, it is necessary to conduct a prospective and continous study in this
wide level.