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Clinical and Laboratory Standards Institute (2011) Susceptibility Testing of Mycobacteria, Nocardiae, and Other Aerobic Actinomycetes; Approved Standard. 2nd Edition, CLSI Document M24-A2, Clinical Laboratory Standards Institute, Wayne.

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• TITLE: Combination of the MODS Assay with the SensititreTM MYCOTB Plate for Rapid Detection of MDR- and XDR-TB

  AUTHORS: Parichat Salee, La’Chia Harrison, Kim Dionne, Carole McArthur, Nicole Parrish

  KEYWORDS: Tuberculosis, Susceptibility Testing, MODS, MYCOTB, MDR-TB, XDR-TB

  JOURNAL NAME: Journal of Tuberculosis Research, Vol.2 No.3, September 3, 2014

  ABSTRACT: We combined the new SensititreTM MYCOTB test with the MODS assay for detection of MDR- and XDR-TB. Categorical agreement of the MODS assay with the critical concentrations at 3 days of incubation was highest for INH (91.4%) and RIF (100%) and at 5 days 86.7% and 94.6% for the fluoroquinolones and aminoglycosides, respectively. By combining these two methods, it is possible to identify MDR-TB in as little as 3 days and XDR- or pre-XDR-TB within 5 days.