TITLE:
Erratum to “Addition of Metanx in Pregabalin Partial Responders for Painful Diabetic Neuropathy”
AUTHORS:
Allen Mark Jacobs, Dunlei Cheng
KEYWORDS:
L-Methylfolate; Methylcobalamin; Metanx; Diabetic Neuropathy
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.4 No.3,
August
29,
2014
ABSTRACT: Objective: To study the effect of addition of Metanxon burning parasthesias in patients with
symptomatic diabetic neuropathy who had obtained only partial symptom
resolution with pregabalin. Research design and methods: This was an open-label
pilot study. There were 16 patients (7 males, 9 females) in the study group and
8 patients (3 males, 5 females) in the control group. A patient numeric rating
scale (0 - 10) of neuropathy associated pain was obtained atbaseline and at 20 weeks. The control group continued on a
fixed dosage of pregabalin without additional medication, while the study group
was supplemented with Metanx(a proprietary blend of bioactive B-vitamins), in addition to
being continued on a fixed dosage of pregabalin. Results:After 20 weeks,
significantly more patients in the study group experienced pain relief compared
to the control group (87.5% vs. 12.5%, respectively, p=0.005). The
average pain score reduction after 20 weeks in the study group was 3 compared
to0.25 inthe control group (p may be used for the relief of pain in patients that
have obtained only partial resolution of symptomatology from pregabalin.