TITLE:
Corneal Cross Linking with Riboflavin for Progressive Keratoconus in Paediatric Eyes
AUTHORS:
Nishant Nawani, Arun K. Jain, Chintan Singh
KEYWORDS:
Corneal Crosslinking, Progressive Keratoconus, Paediatric Eyes
JOURNAL NAME:
Open Journal of Ophthalmology,
Vol.4 No.3,
August
28,
2014
ABSTRACT: Purpose: To report
visual, refractive and topographic outcomes after corneal collagen crosslinking
(CXL) for progressive keratoconus in paediatric eyes. Methods: In this
prospective interventional study, twenty eyes of eighteen patients with
progressive keratoconus were included. All eyes underwent CXL with riboflavin
after documented progression of the disease. Informed, written consent was
taken from the parents of the patients. The patients were followed up for 6 months. Complete ophthalmic examination and Scheimpflug imaging were performed at
each visit. Reduction of the mean refractive cylinder, and corneal flattening
were the main outcome measures. Results: The mean age of the patients was 13.55
years, (range: 9 - 16 yrs). The mean refractive cylinder reduced from a
preoperative value of -5.26D to -4.66D (p = 0.10), -4.31D (p = 0.009), and, -4.10D (p = 0.003) at one, three and six months
(postoperative) respectively. The mean average K value increased from 51.88D to
52.18D (p = 0.64) at one month postoperatively and reduced thereafter to 51.28D
(p = 0.32) and 51.54D (p = 0.02) at three and six months respectively. Thinnest
pachymetry reduced very significantly from a mean preoperative value of 459.15 μm
to 400.8 μm (p