TITLE:
One-Year Outcomes of Women Started on Antiretroviral Therapy during Pregnancy before and after the Implementation of Option B+ in Malawi: A Retrospective Chart Review from Three Facilities
AUTHORS:
Alfred A. Kamuyango, Lisa R. Hirschhorn, Wenjia Wang, Perry Jansen, Risa M. Hoffman
KEYWORDS:
Antiretroviral Therapy, Pregnancy, Option B+, Prevention of Mother-to-Child Transmission
JOURNAL NAME:
World Journal of AIDS,
Vol.4 No.3,
August
28,
2014
ABSTRACT: Objective: To compare
one-year outcomes of women started on antiretroviral therapy (ART) duringpregnancy in the pre-Option B+ era to
those in the Option B+ era. Methods: A retrospective chart review was performed
at three sites in Malawi. Women were included in the “pre-Option B+” cohort if
they started ART during pregnancy for a CD4 count 3or WHO 3/4 condition and in the
“Option B+” cohort if they started ART during pregnancy regardless of CD4 count
or clinical stage. One-year outcomes were compared using Fisher’s exact and
ANOVA F-tests. Results: A higher proportion of women in the pre-Option B+
cohort started ART at WHO stage 3/4 (11.9% versus 1.1%, P