TITLE:
Synchrony between Ovarian Function & Sleep in Polycystic Ovary Syndrome Patients
AUTHORS:
Farideh Zafari Zangeneh, Mohammad Mehdi Naghizadeh, Alireza Abdollahi, Maryam Bagheri
KEYWORDS:
Polycystic Ovary Syndrome (PCOS), Sleep, Stress Hormone, β-Endorphin, Melatonin
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.4 No.12,
August
28,
2014
ABSTRACT: Polycystic ovary syndrome
(PCOS) is a complex, multifaceted, heterogeneous disorder, affecting 4% to 18%
of reproductive-aged women and is associated with reproductive, metabolic and
psychological dysfunction. In this study we determined the relationship between
the time to sleep and serum levels of neurohormones in polycystic ovary
syndrome (PCOS). Totally 77 PCO patients(case group) and 97 non-PCOS infertile
women (control subjects) participated in this study between February 2012 and February 2013. A
PSQI sleep questionnaire was completed by each patient in both groups. PSQI
sleep questionnaire score and serum concentration of adrenaline, noradrenaline,
melatonin, β-endorphin,
cortisol and progesterone were compared in two groups. The results of the study
indicate that serum levels of melatonin and β-endorphin
were lower in women with PCOS. Serum level of stress hormones, adrenaline and
noradrenaline were significantly correlated with patients’ sleep time in study
group. Serum level of adrenaline in control group was significantly lower in
women who wake up earlier in the morning. All hormones except for cortisol had
no significant correlation with PSQI global score in both groups and also the
people who sleep less than 8 hours had lower cortisol level. These data showed
that changes in cortisol in PCO women were
due to damage of disturbed sleep at night. Our preliminary work provided this
study with new insight into the interactions between sleep-wake cycles in PCO
women with specific sleep patterns.