TITLE:
Effect of Sodium Metabisulphite on Blood Metabolic Status of Wistar Rats
AUTHORS:
Fatima Zohra El Kadi, Amina Imène Bénali, Mohammed Bénali, Slimane Belbraouet
KEYWORDS:
Sodium Metabisulphite, Subchronic, Haematology, Biochemistry, Physiology, Wistar Rat
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.5 No.15,
August
27,
2014
ABSTRACT: The objective of this work was to determine
the sodium metabisulphite (NaMBS) subchronic toxicity used
as a food additive in Algeria. Three groups of female Wistar rats were treated
with 0.25%, 1% and 4% of NaMBS in their drinking water for 90 days. An immunization
protocol was conducted during the experiment. Mortality, comportmental and
weight modifications, and food and water consumption were recorded. At the end
of the experiment, the control and experiment rats were killed, and their blood
and organs were removed. Immunoglobulin levels were evaluated; biochemical and hematological
parameters were investigated. Our results showed that the administration of
NaMBS at 1% and 4% had significant effects on body weight, food and water
consumed. There was an increase in biochemical parameters (calcium, urea,
creatinine, uric acid, transaminases) and decrease immunoglobulin levels. The
hematology revealed a decrease in red blood cells and hemoglobin, as well as
leucocytosis. Physiological study showed enlarged spleen, kidney, liver and
stomach. In light of our results, we can conclude that subchronic intake of
NaMBS 1% and 4% seems
to alter immune function, biochemical, hematological and physiological para-meters in Wistar rats.