TITLE:
Enhancement of Gingival Wound Healing by Local Application of Silver Nanoparticles Periodontal Dressing Following Surgery: A Histological Assessment in Animal Model
AUTHORS:
Ghanbari Habiboallah, Zakery Mahdi, Zakeri Majid, Saghravanian Nasroallah, Amir Moeen Taghavi, Ali Forouzanfar, Nooshin Arjmand
KEYWORDS:
Silver Nanoparticles, Wound Healing, Dressing, Periodontal Pack, Wound Dressing, Gingivectomy
JOURNAL NAME:
Modern Research in Inflammation,
Vol.3 No.3,
August
27,
2014
ABSTRACT: Background: The value of
periodontal dressing and its effects on periodontal wound healing have been
questioned. Besides, the early healing of the gingival and periodontal wounds
in oral cavity should be emphasized to promote the treatment outcome. Several
studies pointed out a potential positive effect of silver nanoparticles (NPs)
on the healing process of skin wounds. The present work aimed to design silver
NPs periodontal dressing and then, evaluated its effects on gingival wound
healing following operation. Methods: Thirty healthy adolescent female rabbits
were used in this study. They had intact teeth and the clinical and
radiographic examination revealed no periodontal disease. Silver NPs were added
to carbonate methyl cellulose as base with two different concentrations of 25%
v/v (Group A) and 50% v/v (Group B). On the basis of simple randomized
allocation, gingivectomy was performed at the buccal gingiva of the left and
right mandibular incisors and subsequently, untreated wounds in the control
area were covered with periodontal pack and periodontal dressings A and B were
applied in the test regions. Histological changes were monitored in day 4 and 7
post operation to evaluate the inflammatory and repair stage of healing
process. Results: We observed significant difference in the inflammatory and
repair parameters of the healing process between surgical sites treated with
this periodontal dressing and control group. Besides, wounds treated with
silver NPs dressing in general terms had all the hallmarks of relatively
complete healing one week post operatively. Conclusion: The results indicated
positive potential therapeutic effects for this new formulation of periodontal
dressing on acceleration of surgical wound healing that led to improvement of
periodontal treatment consequences following operation.