TITLE:
Neoplastic-Like CELL Changes of Normal Fibroblast Cells Associated with Evolutionary Conserved Maternal and Paternal Genomic Autonomous Behavior (Gonomery)
AUTHORS:
Kirsten H. Walen
KEYWORDS:
Cytogenetics, Pathologic Cytology, Endomitosis, Division Skewedness, Pathological Mitosis, Metaphase Rosettes, Homozygous, LOH, Growth Pattern, Nutrition, Amino Acid
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.9,
August
27,
2014
ABSTRACT: The present comparative
review discusses conservation of early evolutionary, relic genetics in the
genome of man, which determine two different mechanistic reductive division
systems expressed by normal, human diploid cells. The divisions were orderly
and segregated genomes reductively to near-diploid daughter cells, which showed
gain of a proliferative advantage (GPA) over cells of origin. This fact of GPA
expression is a fundamental requirement for initiation of tumorigenesis. The
division systems were responses to a carcinogen-free induction system,
consisting of short (1 - 3 days) exposures of young cells to nutritional
deprivation of amino acid glutamine (AAD). In recovery growth (2 - 4 days)
endo-tetra/ochtoploid cells and normal diploid metaphase cells demonstrated
chromosomal reductive divisions to respectively heterozygous and homozygous
altered daughter cells. Both division systems showed co-segregating whole
complements, which for reduction of the diploid metaphases could only arise
from gonomeric-based autonomous behavior of maternal and paternal (mat/pat)
genomes. The timely associated appearance with these latter divisions was fast
growing small-cells (1/2 volume-size reduced from
normal diploidy), which became homozygous from haploid, genomic doubling. Both
reductive divisions thus produced genome altered progeny cells with GPA, which
was associated with pre-cancer-like cell-phenotypic changes. Since both
“undesirable” reductive divisions expressed orderly division sequences, their
genetic controls were assumed to be “old genetics”, evolutionarily conserved in
the genome of man. Support for this idea was a search for evidential material
in the evolutionary record from primeval time, when haploid organisms were
established. The theory was that endopolyploid and gonomery-based reductive
divisions relieved the early eukaryotic organisms from accidental,
non-proliferative diploidy and polyploidy, bringing the organism back to vegetative
haploid proliferation. Asexual cycles were common for maintenance of
propagating haploid and diploid early unicellular eukaryotes. Reduction of
accidental diploidy was referred to as “one-step meiosis” which meant
gonomeric-based maternal and paternal genomic independent segregations. This
interpretation was supported by exceptional chromosomal behaviors. However,
multiple divisions expressing non-disjunction was the choice-explanation from
evolutionists, which today is also suggested for the rarer LL-1 near haploid
leukemia. These preserved non-mitotic mechanistic divisions systems are today
witnessed in apomixes and parthenogenesis in many animal phyla. Thus, the
indications are the modern genome of man harbors, relic-genetics from past
“good” evolvements assuring “stable” proliferation of ancient, primitive
eukaryotes, but with cancer-like effects for normal human cells.