TITLE:
Dehydrosulfurization of Aromatic Thioamides to Nitriles Using Indium(III) Triflate
AUTHORS:
Tomoko Mineno, Yu Takebe, Chiaki Tanaka, Sho Mashimo
KEYWORDS:
Indium(III) Triflate, Dehydrosulfurization, Thioamide, Nitriles
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.4 No.3,
August
25,
2014
ABSTRACT: The efficient dehydrosulfurization of thioamides to nitriles was carried out using indium(III) triflate as a catalyst. Based on the results of the initial study, the optimal reaction conditions required 5 mol% of indium(III) triflate with toluene as the practical solvent. Various thioamides were successfully converted to nitriles in high yields.