TITLE:
The Effect of Selenium and Lycopene on Oxidative Stress in Bone Tissue in Rats Exposed to Cadmium
AUTHORS:
Tarfa Al Ibrahim, Hamza Abu Tarboush, Ahmad Aljada, Mai Al Mohanna
KEYWORDS:
Selenium, Oxidative Stress, Lycopene, Cadmium
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.5 No.14,
August
22,
2014
ABSTRACT: This study examined
the effect of selenium (Se) or lycopene (Lyc) and their combination on oxidative
stress in bone following cadmium (Cd) exposure in vivo. Cd exposure enhanced
accumulation of Cd in femur with subsequent
increase in LPO and PC and decreased
antioxidative enzyme activities in rat femur, along with significant decreases
in body and femur bone weights. Subcutaneous (s.c.)
injection of Se or Lyc reduced Cd
accumulation in bone and increased body and femur weights,when given individually or concomitantly. Antioxidant
enzyme activities maintained and/or increased
following Se and Lyc supplementation when
given individually or concomitantly.
However, lycopene dose of 10 mg/kg of body weight
alone or selenium alone provided better protection to bone tissues of rats
against oxidative stress compared to treatment with their combination. Selenium
and lycopene could be used as a dietary supplement to protect against bone
oxidative stress in areas exposed to Cd pollution.