TITLE:
Effect of Diane-35 on Polycystic Ovarian Syndrome of Different Subtypes
AUTHORS:
Yanqin Deng, Xiaoyan Deng, Haiyan Zhou, Yajun Hu, Qing Luo, Jinli Li, Min Wang, Li Liu, Qing Xiao
KEYWORDS:
Daine-35, Polycystic Ovarian Syndrome, Phenotype, Androgen, Antral Follicle Count
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.4 No.11,
August
21,
2014
ABSTRACT: Objective: To explore the
effect of Daine-35 on serum hormone and antral follicle count of different
subtypes of polycystic ovarian syndrome (PCOS). Methods: 138 cases of PCOS were
recruited and typed according to Rotterdam diagnostic criteria; 78 cases of
tubal infertility without hyperandrogenism and menstrual disorders during the
same period were collected as control. Serum reproductive hormones including
follicle-stimulating hormone (FSH), luteotropic hormone (LH), prolactin (PRL),
estradiol (E2), dehydroepiandrosterone (DHEAS), total testosterone (TT) and
fast insulin (INS) were determined by chemiluminescent immunoassay. Ovarian
antral follicle count was determined by ultrasonography. The effects on above
indexes were evaluated for different subtypes of PCOS after 3 cycles of
treatment with Daine-35. Results: The cases of Type A and Type B were
respectively 43 (31.2%) and 73 (52.9%). They were the most common clinical
phenotypes of PCOS in the central region ofChina. Total testosterone (TT) and
DHEAS levels of Types A, C and D were higher than those of the control group (p
0.05). The serum LH and LH/FSH as well as the antral
follicle count of all the PCOS types significantly decreased (p