TITLE:
The molecular mechanism for DDT detoxification in Anopheles gambiae: A molecular docking study
AUTHORS:
William N. Setzer
KEYWORDS:
Malaria; DDT; Anopheles Gambiae; Glutathione S-transferase; Docking
JOURNAL NAME:
Journal of Biophysical Chemistry,
Vol.2 No.2,
June
2,
2011
ABSTRACT: The epsilon class glutathione-S-transferase of Anopheles gambiae, agGSTe2, is capable of metabolizing DDT. A molecular docking analysis of DDT with agGSTe2 support an E2 elimination mechanism wherein the glutathione sulfur
serves as the base to convert DDT to DDE.