TITLE:
Adipose Derived Stem Cells and Growth Factors Applied on Hair Transplantation. Follow-Up of Clinical Outcome
AUTHORS:
Federica Zanzottera, Emilio Lavezzari, Letizia Trovato, Alessandro Icardi, Antonio Graziano
KEYWORDS:
Stem Cell, ADSC, Hair Transplantations, Regenerative Medicine, Hypoderm Hair Transplantations
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.4 No.4,
August
20,
2014
ABSTRACT: Different studies show the need
of immature adipose cell to induce the proliferation of bulge stem cells in
order to kick off the anagen phase of hair cycle. Furthermore, the adipose
derived stem cell, adipose progenitors, and growth factors secreted by mature
adipocytes can help the wound healing and the vascular neogenesis. Nowadays, it
is not known any protocol of tissue regeneration applied to hair
transplantation, especially if aimed to the reconstruction of the main vascular
network for the engraftment of transplanted hair and the healing process. The
aim of the work is to investigate how the application of autologous cellular
suspension obtained by Rigenera system, mechanical fragmentation procedure
which allows to obtain a physiological saline solution consisting of a heterogeneous pool of cells rich in adipose derived
mesenchymalstem cells and growth factors, helps the wound healing and
engraftment of the transplanted hair. During hair restoration surgery, the
adipose tissue recovered from the discard of follicular slicing, was processed
using the Rigenera system. The obtained cell suspension was applied in the area
of hair transplantation, increasing the natural background of adipocyte lineage
and raising the amount of growth factors. In addition, the cellular suspension
was applied to the suture on the occipital region. The cell population was
characterized by FACS. The monthly evaluation of hair transplantation follow-up
with photos and the patient’s impressions demonstrates that there is a faster
healing of the micro-wound and a continuous growth of the transplanted hair
even two months after the procedure, with a shortening of the dormant phase. In
conclusion, this new approach aims to integrate regenerative medicine and hair
restoration surgery in order to improve the outcome for the patient. It would
be wonderful to continue this research to elaborate on the molecular cause
behind this satisfying clinical.