TITLE:
Genital Warts in Infants and Children —Re-Evaluation of Podophylline 15% as an Effective Topical Therapy
AUTHORS:
Khalifa E. Sharquie, Adil A. Noaimi, Mohammed N. Almallah
KEYWORDS:
Genital Warts in Infants and Children, Podophylline, Topical Therapy
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.4 No.4,
August
19,
2014
ABSTRACT: Background: Condylomataacuminata
is an infection caused by Human Papilloma Virus, rarely reported in infants and
children. Podophylline as a treatment for this condition has been used cautiously
in this age group. Objective:
To report the cases of anogenital warts including condy lomataacuminata in
infants and children and to evaluate the effectiveness and side effects of 15%
podophyllin in treatment of genital warts. Patient and Methods: Thirty infants and young children were seen
in Department of Dermatology and Venereology—Baghdad
Teaching Hospital in this case descriptive and therapeutic trial, in the period
from January 2011 to August 2012. Their ages ranged from 8 - 72 (30.43 ± 15.85)
months, 20 females and 10 males with a female:male ratio of 2:1. The duration
of the disease ranged from 1 - 12 (5.26 ± 4.00) months. All demographics data
were recorded in this study. History and examination were carried out to all
patients. Family members including mothers were assessed about the presence of
any type of viral warts in other location of body. Podophyllin (15%) in
tincture benzoin was applied once weekly to all viral warts and the parents
advised to wash out after 2 hours of application. The number of applications
was repeated until full recovery. Follow-up after recovery was carried out for
6 months to watch for any relapse and to record local or systemic side effects.
Results: The clinical pictures
were mostly acondylomata acuminata in a form of cauliflower like warts in 20
(73.33%) patients, while in 10 (26.77%) patients there were ordinary verruca
vulgaris like warts. The location of warts was perianal in 23 (76.66%)
patients, genital only in 2 (6.66%) patients, and mixed in 5 (16.66%) patients.
Topical applications of podophyllin 15% gave a full recovery in 27 (90%)
patients, while in 3 (10%) patients there was partial response. The number of
applications ranged from 1 - 4 (2.7 ± 1.42) applications. Follow up for 6
months after recovery showed relapse in only one patient, and no side effects
were reported in any patients. Conclusion:
There is upsurge of cases of anogenital warts among infants and children.
Podophyllin (15%) in tincture benzoin is an effective therapy and no local or
systemic side effects were recorded in any case.