TITLE:
Clinical Implications of Tumor Necrosis Factor-Alpha, Interleukin-6 and Resistin in Coronary Artery Disease
AUTHORS:
Qamar Javed
KEYWORDS:
Tumor Necrosis Factor-Alpha, Interleukin-6, Resistin, Coronory Heart Disease, Gene Polymorphism
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.4 No.9,
August
19,
2014
ABSTRACT: Tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) are
involved in the progression of coronary artery disease (CAD). The cytokines’
levels are associated with the severity of CAD. We have recently reported on
the association of resistin, a relatively novel cytokine with the pathogenesis
of cardiovascular disease (CVD). Although the inflammatory cytokines’ impact on
atherosclerosis is widely accepted, yet some controversy exists regarding the
involvement of these factors in atherogenesis. The current review highlights
the potential association of TNF-alpha, IL-6 and resistin SNPs (single
nucleotide polymorphisms) with CAD. Molecular genetics data along with the
intracellular signaling cascade mechanisms may have important clinical implications
in the treatment of CAD.