TITLE:
Utility of C-Reactive Protein and Procalcitonin for Detecting Bloodstream Infection in Patients with HIV/AIDS
AUTHORS:
Arianna Castillo Marshall, Tersilia García Castellanos, Isabel Martínez Motas, Daniel Salazar Rodriguez, María Eugenia Toledo Romaní, Jorge Pérez Ávila
KEYWORDS:
Acute Renal Injury, Surgical Hemostasis, Absorbable Implants, Inflammation, Biocompatible
JOURNAL NAME:
World Journal of AIDS,
Vol.4 No.3,
August
18,
2014
ABSTRACT: Human immunodeficiency
virus (HIV) infected persons, are at high risk for developing a bloodstream
infection. In order to evaluate the usefulness of C-reactive protein (CRP) and
procalcitonin (PTC) in the detection of bloodstream infection in HIV, a
case-control study was conducted from February to December 2012. PCT and CPR
levels were measured in 2 groups. PCT concentrations were measured by the VIDAS®Brahms PCT assay, and CRP
concentrations were determined by CRP latex. Values were calculated for both
biomarkers and discriminative ability of PCT and CRP was analyzed using ROC
curves. There were no significant differences between the study group and the
control groups with respect to CRP levels. However, they were much higher PCT
levels in patients with bacteremia. PCT showed greater discriminating ability
compared to CRP, and proved to be a valuable tool for the detection of systemic
bacterial infections in HIV infected patients.