TITLE:
Weight Loss Impact on Change in Depression in Type 2 Diabetes Mellitus: Study to Help Improve Early Evaluation and Management of Risk Factors Leading to Diabetes (SHIELD)
AUTHORS:
Susan Grandy, Andrew J. Green, Kathleen M. Fox
KEYWORDS:
Depression, Type 2 Diabetes Mellitus, Weight Loss
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.4 No.3,
August
13,
2014
ABSTRACT: Objectives: This study
evaluated the association between weight loss and change in depression among
patients with type 2 diabetes mellitus (T2DM). Methods: Weight change from 2008
to 2009 among respondents (with and without T2DM) in the Study to Help Improve
Early evaluation and management of risk factors Leading to Diabetes (SHIELD)
was calculated. Change in depression was calculated as change from 2008 to 2009
in Patient Health Questionnaire-9 (PHQ-9) scores. Respondents with weight loss
(>1%, >3%, >5%) were compared with respondents with weight gain (≥1%).
Multivariate regression adjusted for baseline characteristics. Results: Among
those with T2DM, more respondents with weight loss (n = 779) improved their
depression scores, compared with respondents with weight gain (n = 731): 32.9%,
36.9%, 39.8% for >1%, >3%, and >5% weight loss, respectively, vs.
28.7% for weight gain (p1%, 2.96 for >3%, and 3.31 for >5%
weight loss, p