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Ishikawa, J., Narita, H., Kondo, N., Hotta, M., Takagi, Y., Masukawa, Y., Kitahara, T., Takema, Y., Koyano, S., Yamazaki, S. and Hatamochi, A. (2010) Change in Ceramide Profile of Atopic Dermatitis Patients. Journal of Investigative Dermatology, 130, 2511-2514. http://dx.doi.org/10.1038/jid.2010.
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has been cited by the following article:

• TITLE: Efficacy Evaluation of Unique Skincare Product Containing Pseudo-Ceramide for Fine Wrinkles in Japanese Female Atopic Dermatitis Patients

  AUTHORS: Akihiko Takahashi, Katsura Mori, Takahiro Nishizaka, Hisateru Tanabe

  KEYWORDS: Pseudo-Ceramide, Fine Lines, Wrinkles, Atopic Dermatitis, Clinical Trial

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.4 No.4, August 12, 2014

  ABSTRACT: Background/Objective: Dryness is considered to be an early developmental mechanism of wrinkles, and fine line formation is marked in atopic dermatitis (AD) accompanied by dry skin. To evaluate the efficacy of a skincare product with a moisturizing effect increased by lamellar formulation of pseudo-ceramide for fine lines and wrinkles, a use test was performed applying the product to non-lesional dry skin in patients with atopic dermatitis. Method: The test product was an essence containing pseudo-ceramide formulated in a lamellar structure. The study design was a nine-week single-center non-comparative study, and the evaluation items were the grade of wrinkles at the corners of the eyes judged by a dermatologist, replica analysis, and instrumental measurement (skin surface moisture and transepidermal water loss). Results: Nine-week continuous use of the test product significantly improved the score of wrinkles at the corners of the eyes judged by a dermatologist and wrinkle area ratio on replica analysis of the corners of the eyes and cheeks, compared with those at study initiation. With this improvement, the losses of skin surface moisture and transepidermal water were also significantly improved. Conclusion: It was clarified that the tested pseudo-ceramide-formulated skincare product not only improved the barrier function for atopic dermatitis, but also exhibited an effect on fine lines and wrinkles of dry skin.