TITLE:
Impact of Helicobacter pylori Infection on Serum Lipid Profile and Atherosclerosis of Carotid Artery
AUTHORS:
Hadeel A. Ibrahim, Mohammed O. Mohammed, Hawa A. R. Dhahir, Kawa A. Mahmood, Bryar E. Nuradeen
KEYWORDS:
Dyspepsia, H. pylori, Lipid Profile, Atherosclerosis
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.5 No.15,
August
11,
2014
ABSTRACT: Background: Helicobacter pylori (H. pylori)
infection has been suggested to be associated with atherosclerosis. The issue is
still controversial. It is well known that abnormal lipid profile is related to
atherosclerosis and measurement of carotid intima-media thickness. Aim of the study:
to investigate carotid intima-media thickness and lipid parameters in H. pylori-positive and
-negative subjects. Materials & Methods: This study was conducted in Kurdistan
Teaching center of Gastroenterology and Hepatology (KCGH) in Sulaimani city during
the period of December 2012 to March 2014. One hundred dyspeptic patients with H. pylori infection and 74 apparently healthy asymptomatic volunteers
with H. pylori-negative
tests were enrolled in this study. Both groups were comparable in age distribution
and gender. H. pylori infection (IgG & IgA) were assessed by ELISA tests, Triglyceride, total cholesterol,
low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol
(HDL-C) concentrations were measured by routine enzymatic methods using commercial
kits. Carotid intima-media thickness was assessed by high-resolution ultrasound.
Results: The mean and maximum values
of internal and common carotid intima-media thickness in H. pylori-positive subjects were
significantly thicker than in H. pylori-negative subjects (p H. pylori seropositive)
than in controls (seronegative subjects), total cholesterol, LDL-C and triglyceride
level were found to be higher in patients than in controls (p H. pylori-positive
subjects. These data indicated that H. pylori infection may had a role in atherosclerotic process.