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Khan, E.A. and Starke, J.R. (2006) Diagnosis of Tuberculosis in Children: Increased Need for Better Methods. International Journal of Tuberculosis and Lung Disease, 10, 1091-1097.

has been cited by the following article:

• TITLE: Stool as Appropriate Sample for the Diagnosis of Mycobacterium tuberculosis by Gene Xpert Test

  AUTHORS: Seble Haile Welday, Andrew Nyerere Kimang’a, Beatrice Muthoni Kabera, Josphine Wahogo Mburu, Christina Mwachari, Elizabeth Mungai, Stanley Mugambi Ndwiga, Joseph Kariuki Mbuthia, Gunturu Revathi

  KEYWORDS: Pulmonary Tuberculosis (PTB), Pediatric, Stool, Xpert MTB/RIF, Smear Microscopy, Mycobacterium tuberculosis

  JOURNAL NAME: Open Journal of Respiratory Diseases, Vol.4 No.3, August 11, 2014

  ABSTRACT: Background: Diagnosis of pediatric pulmonary tuberculosis (PTB) is a challenge. Symptoms are nonspecific. Young children are unable to expectorate sputum samples; the procedures for obtaining respiratory samples are invasive. Thus Mycobacterium tuberculosis cultures and smears often are not performed. Stool samples were used as an alternative to respiratory samples for the diagnosis of pediatric PTB using stool Xpert MTB/RIF and its sensitivity for detecting the DNA of MTB in stool was determined. Methods: The study was a laboratory-based cross-sectional prospective design. Stool specimen was collected from PTB suspected children (Mycobacterium tuberculosis DNA can be detected in stool using Xpert testing with a higher sensitivity. Therefore stool which can easily be obtained is an appropriate alternative sample for the diagnosis of PTB using Xpert assay for children unable to give respiratory samples. Furthermore Xpert turn round time is less than 2 hours.