TITLE:
The Associations for Vaginal Point Doses of Vaginal Stenosis in Image-Guided Brachytherapy
AUTHORS:
Ekkasit Tharavichitkul, Rungtip Jayavasti, Razvan M. Galalae, Damrongsak Tippanya, Sukon Prasitwattanaseree, Wannapa Nobnop, Somvilai Chakrabandhu, Pitchayaponne Klunklin, Wimrak Onchan, Somsak Wanwilairat, Imjai Chitapanarux
KEYWORDS:
Image-Guided Brachytherapy, Vaginal Dose Point, Vaginal Stricture, Associations
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.9,
August
7,
2014
ABSTRACT: Purpose: To evaluate the
associations for vaginal dose points of vaginal stricture in image-guided
brachytherapy. Materials and Methods: Twenty-six patients of locally advanced
cervical cancer were treated with Image-Guided Brachytherapy (IGBT) with the
dose at least 7 Gy per fraction to the D90 of High-Risk Clinical Target Volume
(HR-CTV). The vaginal dose points of recommendations of the American
Brachytherapy Society (ABS) were added into the plan and cumulative dose to
these points was evaluated in Equivalent Dose of 2 Gy (EQD2) concepts. Results:
The mean doses to right vaginal dose point (VR), left vaginal dose point (VL)
and average dose of VR/VL ((VR + VL)/2) were 101.5 Gy, 98.2 Gy and 99.8 Gy in
EQD2 concepts, respectively. Volume-based planning significantly reduced the
cumulative dose in EQD2 concepts at vaginal points. At the median follow-up
time of 22 months, grade-2 vaginal stricture was observed in two patients. The
incidences of vaginal stricture were not differed between the cumulative dose
to vaginal dose points in EQD2 concepts of ≤90 Gy versus >90 Gy (P = 1.000)
and ≤100 Gy versus >100 Gy (P = 0.815). Conclusion: No association for
cumulative vaginal doses and events of vaginal stricture was found.