TITLE:
Epstein-Barr Virus Positive Inflammatory Pseudotumor of the Spleen: Case Report and Review of the Literature
AUTHORS:
Slim Jarboui, Abelwaheb Hlel, Med Ali Bekkay, Habib BelHaadj Khalifa, Moncef Mokni
KEYWORDS:
Inflammatory Pseudotumor, Spleen, Splenectomy, Epstein-Barr Virus
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.3 No.8,
August
7,
2014
ABSTRACT: Inflammatory
Pseudotumor (IPT) forms a group of etiologically, histologically, and
biologically heterogeneous tumefactive lesions that are histologically
characterized by prominent inflammatory infiltrates. It has been described in
various organs including the lungs, bladder, liver, spleen, heart, and others.
It may mimic a malignant tumor clinically and radiologically. Splenic IPT are
most frequently detected incidentally. We report a case of 38-year-old women
admitted for recurrent abdominal pain. Physical examination was unremarkable.
Contrast enhanced CT showed a well hypodense, circumscribed lesion, measuring 5
× 3.5 cm. A differential diagnosis of lymphoma, teratomas, angioma or
angiosarcoma was considered. The patient underwent splenectomy. Histologically,
the tumor consisted of an inflammatory infiltrate composed predominantly of
diffusely lymphoplasmocytic cells and stromal fibroblasts. Epstein-Barr virus
was detected on in situ hybridization
exclusively in the epitheloid and spindles cells. The optimal management of
this tumor and eventually in asymptomatic patients is still controversial. IPT
of the spleen should be remembered when evaluating single or multiple nodules
in spleens. The clinical and pathological features of previously reported cases
are reviewed in this paper.