TITLE:
The Transcription Factors GATA-1 and GATA-4 Have Opposite Effects on DNA Expression Driven by an Amh Promoter
AUTHORS:
David W. Dresser
KEYWORDS:
SMAT-1, Mouse Pre-Pubertal Sertoli, In Vitro, Amh Promoter, d2EGFP, Transcription Factors, GATA-1, GATA-4
JOURNAL NAME:
American Journal of Molecular Biology,
Vol.4 No.3,
July
31,
2014
ABSTRACT: An Amh promoter
driving expression of a reporter gene (d2EGFP) has been used to analyze the
role of two specific promoter transcription factor binding elements. In
addition a downstream (3’) enhancer (DE) was also investigated. The
transcription factors GATA-1 and GATA-4 had opposite effects, the former being
incremental and the latter decremental. The quantitative balance between these two
factors may provide a degree of control over the level of gene expression.