TITLE:
Melatonin and Circadian Rhythm: Aging, Cancer, and Mechanism
AUTHORS:
Peter Kovacic, Ratnasamy Somanathan
KEYWORDS:
Melatonin, Circadian Clock, Aging, Cancer, Mechanism
JOURNAL NAME:
Open Journal of Preventive Medicine,
Vol.4 No.7,
July
29,
2014
ABSTRACT: The circadian clock
is involved with many aspects of biological processes in animals and plants.
Melatonin is a pineal hormone which is known to play a widespread role in the
biochemistry of the circadian clock. The present review addresses the clock and
melatonin in relation to aging and cancer, which are important aspects of
medicine and biochemistry. The literature contains a large variety of associations
of these areas with melatonin and circadian rhythm. Mechanistic aspects are
addressed with emphasis on the unifying theme based on electron transfer-free
radicalsoxidative stress.