TITLE:
Enhancement of Periodontal Healing by Application of a Novel Ointment Compared with Hyaluronic Acid, Histological Observation in Animal Model
AUTHORS:
Ghanbari Habiboallah, Zakeri Mahdi, Saghravanian Nasroallah, Zakeri Massoud, Baradaran Nasseri Ehsan, Zareian Jahromi Mina, Sardari Kamran
KEYWORDS:
Anti-Inflammatory, Healing, Hyaluronic Acid, Ghee, Periodontal Flap Surgery, Animal Model
JOURNAL NAME:
Modern Research in Inflammation,
Vol.3 No.3,
July
24,
2014
ABSTRACT: Objectives:The early healing of
the periodontal wound in oral cavity may be critical to the treatment outcome.
Thus, we made a novel ointment based on natural constituents that our recent
investigation suggested a positive therapeutic effects on gingival wounds. The
present study was conducted to evaluate the role of this novel biomaterial on
periodontal wound healing including soft as well as hard tissue. Materials and
Methods: Experimental periodontitis was induced by wire tied around the
cement-enamel junction of I2, P1, P3and
M1in six adult, healthy beagle dogs. After 3 months,
mucoperiostal flap elevated and root surfaced was thoroughly scaled and planed.
Randomly, three materials including our ointment with two different ratios
including materials A and B and hyluronic acid were applied topically and then
the flaps were repositioned and sutured. Three dogs at day 7 and the three
remaining ones two weeks post-surgery were sacrificed and histological changes
were monitored. Results: The result of this study showed that the local
applications of this novel ointment promoted the healing process particularly
fibroblast proliferation and collagen density remarkably in comparison with
hyaluronic acid and control group. Besides, histological finding of our
material revealed that in general terms had all the hallmarks of complete
healing two weeks post operatively. Conclusion: Our novel material appeared to
have outstanding effect on periodontal wound healing which can improve the
periodontal healing consequences and provide better strength of periodontal
wound flap. From a clinical standpoint, it could play an important role for
better repair in diabetic patients who frequently present difficulties in
mucosal and cutanous wound healing.