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Bourdon, K.H., Rae, D.S., Locke, B.Z., Narrow, W.E. and Regier, D.A. (1992) Estimating the Prevalence of Mental Disorders in US Adults from the Epidemiologic Catchment Area Survey. Public Health Reports, 107, 663-668.

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• TITLE: Effects of Lithium and Valproic Acid on the Production of Brain-Derived Neurotrophic Factor in Astrocytoma

  AUTHORS: Koji Ohtomo, Satoshi Nishino, Masatake Kurita, Hirobumi Mashiko, Shin-ichi Niwa

  KEYWORDS: BDNF, Bipolar Disorder, Lithium, PLCγ, TrkB, Valproic Acid

  JOURNAL NAME: Open Journal of Psychiatry, Vol.4 No.3, July 22, 2014

  ABSTRACT: No systematic investigation considering BDNF and its receptor TrkB has been conducted on the effects of mood-stabilizing drugs. We therefore decided to quantify BDNF production and the expression of TrkB-T1 receptor and PLCγ in astrocytoma. 1321N human astrocytoma cells were grown to a sufficient quantity in 5% fetal calf serum (FCS). The mood-stabilizing drugs Li and VPA were added to the therapeutic concentrations of 1 mM and 600 μM, respectively. The production of BDNF was determined by an enzyme-linked immunosorbent assay. The expressions of TrkB-T1 and PLCγ were determined by Western blot. The production of BDNF was significantly higher on Day 7 in the VPA samples (P γ expression did not change. Li and VPA seem differently affect BDNF production and TrkB-T1 (BDNF receptor) expression.