TITLE:
Recent Advances in the Chemistry of Oripavine and Its Derivatives
AUTHORS:
Sandor Hosztafi
KEYWORDS:
Papaver orientale, Papaver somniferum, Oripavine, Thebaine, Top1 Poppy
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.5 No.8,
July
21,
2014
ABSTRACT: Oripavine is the
major alkaloid of Papaver orientale.
It is an important intermediate in the biosynthesis of morphine alkaloids.
Recently, new Papaver somniferum strains have been developed which accumulate thebaine and oripavine, but not
morphine and codeine. Therefore, the chemistry of oripavine has been studied
intensively to synthesize opioid pharmaceuticals such as oxymorphone, naloxone
and buprenorphine.