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Howard, A. and Pelc, S.R. (1953) Synthesis of Deoxyribonucleic Acid in Normal and Irradiated Cells and Its Relation to Chromosome Breakage. Heredity, 6, 261-273.

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• TITLE: Probing the Cell Cycle with Flow Cytometry

  AUTHORS: George D. Wilson

  KEYWORDS: Flow Cytometry, Cell Cycle, DNA Profile, Bromodeoxyuridine, Cyclins

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.7 No.9, July 21, 2014

  ABSTRACT: Flow cytometry is a versatile technique to study different aspects of the cell cycle from subpopulations of cells to detailed cell kinetic information. In this paper a basic review of cell kinetic parameters is presented followed by detailed descriptions of the different flow cytometric methodologies that can be used to extract pertinent information for a particular study. The methodologies range from simple DNA profile analysis, the use of bromodeoxyuridine to cell cycle-associated proteins such as the cyclins.