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Almeida, R., Almeida, J., Shoshkes, M., Mendes, N., Mesquita, P., Silva, E., Van Seuningen, I., Reis, C.A., Santos-Silva, F. and David, L. (2005) OCT-1 Is over Expressed in Intestinal Metaplasia and Intestinal Gastric Carcinomas and Binds to, But Does Not Transactivate, CDX2 in Gastric Cells. The Journal of Pathology, 207, 396-401.
http://dx.doi.org/10.1002/path.1861

has been cited by the following article:

• TITLE: Absence of Expression of OCT-2 in Gastric Cancer Cells

  AUTHORS: José Paulo Freire, Maria Emilia Oliveira, Maria Conceição Crujo, Ana Rute Fernandes, José Crespo Mendes de Almeida, Henrique Bicha Castelo

  KEYWORDS: Gastric Cancer, Lymph Node Metastasis, OCT-2, Stem Cells

  JOURNAL NAME: American Journal of Molecular Biology, Vol.4 No.3, July 16, 2014

  ABSTRACT: OCT-2, a member of the POU homeodomain family of transcription factors, has been implicated in gastric cancer lymph node metastasis on a single publication so far. Other members of the same family of transcription factors were found to have a role in intestinal metaplasia and gastric cancer (OCT-1) and in trophectoderm differentiation of embryonic stem cells (OCT3/4) via modulation ofCDX2. These findings prompted us to evaluate whether OCT-2 could in fact have a role in gastric oncogenesis and lymph node metastasis in human gastric cancer, designing an immunohistochemistry study of the putative expression of OCT-2 on human gastric cancer tissue of 69 surgical archival specimens of intestinal and diffuse type. We could not find expression of OCT-2 on any of our cancer tissues, metaplasia or normal gastric mucosa despite the expression of OCT-2 on tonsil lymphatic cells (tissue test) and normal lymph nodes. We concluded that, based on immunohistochemistry, OCT-2 does not have a role in gastric oncogenesis nor does have any relationship with lymph node metastasis in gastric cancer.