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Everaere, K., Mortreux, A., Bulliard, M., Brussee, J., van der Gen, A., Nowogrocki, G. and Carpentier, J.F. (2001) (β-Amino alcohol)(arene)ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation of Functionalized Ketones-Scope, Isolation of the Catalytic Intermediates, and Deactivation Processes. European Journal of Organic Chemistry, 2001, 275-291.

has been cited by the following article:

• TITLE: The Nature of the True Catalyst in Transfer Hydrogenation with Alcohol Donors Using (arene)2Ru2Cl4(II)/TsDPEN Precursor

  AUTHORS: Judith Toubiana, Liraz Medina, Yoel Sasson

  KEYWORDS: Catalytic transfer Hydrogenation (CTH), Asymmetric Transfer Hydrogenation (ATH), Ruthenium Nanoparticles, Ruthenium Complexes, Nanocatalyst, Chiral Nanoparticles

  JOURNAL NAME: Modern Research in Catalysis, Vol.3 No.3, July 15, 2014

  ABSTRACT: The widespread precatalyst (prepared in-situ or ex-situ) (arene) RuTsDPEN advocated for highly effectual asymmetric transfer hydrogenation (ATH) reactions with 2-propanol as hydrogen donor at ambient conditions, is proven to be unstable under the strong reducing conditions prevailing in the reaction mixtures (blend of alcohol and a base such as KOH). We assert that the true catalysts are the ruthenium metal nanoclusters formed swiftly under the reducing conditions of these systems. The TsDPEN ligand plays a critical role in the generation and formatting of the active catalyst including wreaking chiral properties to the so formed catalytic nanoparticles. Kinetic measurements, NMR, UV-visible spectroscopy, circular dichroism (CD) and TEM analyses corroborate this argument.