TITLE:
Metastatic Carcinoma of the Uterine Cervix from Rectal Carcinoma: A Case Report and Review of the Literature
AUTHORS:
Motoki Matsuura, Masato Tamate, Masahiro Suzuki, Tasuku Mariya, Sakura Takada, Yuta Tabuchi, Mizue Teramoto, Seiro Satohisa, Ryoichi Tanaka, Masahiro Iwasaki, Kaori Fukunaka, Noriyoshi Fukunaka, Satoshi Tanaka, Tsuyoshi Saito
KEYWORDS:
Metastatic Adenocarcinoma, Cervical Cancer, Colorectal Carcinoma
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.4 No.10,
July
15,
2014
ABSTRACT: Primary adenocarcinomas of
the uterine cervix account for 5% - 15% of all cervical malignancies, but
secondary adenocarcinomas from extragenital cancers are rare. Only 35 cases
have been reported in the literature since 1941. We report a 52-year-old
Japanese woman who had been treated for rectal adenocarcinoma (Dukes C, stage
IIIb) and who was diagnosed with primary uterine cervical carcinoma (FIGO stage
Ib2) two years later. A radical hysterectomy was performed and the
surgical specimen showed metastatic adenocarcinoma of the uterine cervix from
rectal cancer without direct extension. Immunohistochemical staining was
positive for cytokeratin 20 and CDX2, and negative for cytokeratin 7. Immunohistochemical
staining is important for distinguishing between primary and secondary
adenocarcinomas of the cervix, but histologic findings alone are not always
adequate to establish the site of the primary lesion. The distinction between
primary and secondary adenocarcinomas of the cervix is important for patient
management and prognosis. Therefore, the possibility of metastatic
adenocarcinoma should be considered whenever a diagnosis of adenocarcinoma of
the cervix is received.