TITLE:
Endosulfan Causes Neoplastic Changes in the Liver Cells of Mice
AUTHORS:
Arun Kumar, Mohammad Ali, Jitendra Kumar Singh, Akhileshwari Nath, Sudhir Kumar Srivastava, Ranjit Kumar
KEYWORDS:
Endosulfan, Neoplasia, Liver Cell, Light Microscopy, Transmission Electron Microscopy
JOURNAL NAME:
Open Journal of Pathology,
Vol.4 No.3,
July
14,
2014
ABSTRACT:
The rapid growth in
global population continues to challenge the world’s ability to provide enough
food. As one of the most crucial issues for human development, food production
must increase to offset hunger and poverty as well as social unrest. To augment
the yield of crops a variety of pesticides like Endosulfan, Rogor, Aldrin, Chlorpyrifos,
etc. are being used liberally by the farmers. In the present investigation,
Endosulfan was administered orally (daily) by gavage method to female Swiss
albino mice group for 4 weeks @ 3.0 mg/kg b.w. After that, they were left for 6
months and then sacrificed and liver tissues were fixed for light microscopy
and Transmission Electron Microscopic study. The histopathological study of
Endosulfan administered group liver showed hepatocytes with congestion in
central vein with less dense cytoplasm, haemorrhaged bile duct, degenerated
cytoplasm and central vein with vacuolations in sinusoidal spaces. Neoplastic
changes in hepatocytes are the major finding of study. The ultrastuctural study
revealed dilation in the nuclear pore complex and massive movement of cytoplasmic
material from cytoplasm to the nucleus which is major finding which denotes
neoplastic changes. Presence of abundant free lying polyribosomes in the
cytoplasm, which denotes neoplastic changes in the cellis also one of
theimportant finding observed. The present study thus deciphers that Endosulfan
toxicity leads to onset of neoplasia thence carcinogenesis in liver cells in Swiss
albino mice which is the novel finding in the field of toxicology.