TITLE:
Patient with Metastatic Breast Cancer Achieves Stable Disease for 5 Years on Graviola and Xeloda after Progressing on Multiple Lines of Therapy
AUTHORS:
Damien Mikael Hansra, Orlando Silva, Ashwin Mehta, Eugene Ahn
KEYWORDS:
Breast Cancer, Graviola, Therapy
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.3 No.3,
July
1,
2014
ABSTRACT: Breast cancer (BC) is the
most common malignancy in women and is second to lung cancer in terms of cancer
mortality. Treatment of BC remains a challenge as current therapies are limited
by toxicity and drug resistance. Graviola (Annona muricata) is a tree
that grows in the tropics of North and South America. Traditionally, the leaves
and stems from the graviola tree have been used for a wide range of human
diseases including cancer.In
vitroandin vivostudies demonstrate anticancer
activity in BC however clinical studies are lacking. We present the first case
demonstrating clinical benefit without side effects using graviola in a patient
with BC whose disease was refractory to multiple lines of chemotherapy
including anthracyclines and taxanes.