TITLE:
Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1H-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate
AUTHORS:
Yang Liu, Guanghui Tian, Hongguang Ge, Xiaoyan Cao, Daihua Hu, Dehua Zhang
KEYWORDS:
Anticancer Nucleosides, Intermediate, Triazole Nucleosides
JOURNAL NAME:
Journal of Crystallization Process and Technology,
Vol.4 No.3,
June
30,
2014
ABSTRACT: An
important anticancer nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5-(3-bromo-5-(methoxycar-bonyl)-1H-1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl
diacetate was synthesized by directly coupling the bromotriazole with the
protected ribose sugar, and have given the corresponding product in moderate
yield. Its structure and conformation were confirmed by single crystal X-ray
diffraction.