TITLE:
A Competing Risk Hazard Model for Complications of Diabetes Mellitus
AUTHORS:
Parvin Akter Khanam, Mohammed Ataharul Islam, Mohammed Abu Sayeed, Tanjima Begum, Mohammed Golam Rabbani, Subhagata Choudhury, Hajera Mahtab
KEYWORDS:
Family History of Diabetes, Educational Level, Type 2 Diabetes Mellitus, Coronary Heart Disease, Mean Arterial Blood Pressure
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.2 No.5,
June
30,
2014
ABSTRACT: Diabetes mellitus is a major public health problem globally. It is the cause of serious and sometimes life-threatening complications leading to death. It is one of the most common non communicable diseases and leading cause of death in most developed countries including Bangladesh. It is associated with the increased risk of microvascular (nephropathy and retinopathy), macrovascular (cardiovascular diseases, stroke) and other mixed (cataract, pulmonary tuberculosis, foot ulcer etc.) complications. The aim of this study was to determine the risk factors related to diabetes complications and to propose competing risk models for analyzing complications of diabetes mellitus. We study 2887 diabetic patients from the BIRDEM registry record books for the period from 1984 to 1997 who have at least two follow-up visits and who are free from complications at the first visit. The data on variables such as 2-hBG, age, sex, family history of diabetes, area of residence, educational level, BMI, SBP, DBP and treatment status are obtained. Also, the time from the diagnosis of type 2 diabetes mellitus (T2DM) to the occurrence of complications was recorded. We use the competing risk hazard model and examined the potential risk factors for determining the development of such complications. This study reveals that increase in blood pressure is a potential risk factor for CHD and nephropathy in T2DM. We also found that male and illiterate patients are more affected by nephropathy. In our study, we also revealed that female and illiterate patients are also more influenced by cataract.