TITLE:
Hepatoprotective and Antioxidant Effects of Salvia officinalis L. Hydroalcoholic Extract in Male Rats
AUTHORS:
Khakpour Shahrzad, Najari Mahya, Tokazabani Belasei Fatemeh, Khosravi Maryam, Farhadi Belasei Mohammadreza, Mahsa Hadipour Jahromy
KEYWORDS:
Salvia officinalis L., Antioxidant Effects, Rat
JOURNAL NAME:
Chinese Medicine,
Vol.5 No.2,
June
27,
2014
ABSTRACT: The antioxidant effects of Salvia officinalis L. hydroalcoholic extract and also
its hepatoprotective effects in male rats were evaluated. Salvia officinalis L. extract was administered intraperitoneally for 28 days. Serum levels of
aspartate aminotransferase, alanine transferase and alkaline phosphates in rats
coadministered with both isoniazid (INH) 50 mg/kg and Salvia officinalis L. extract at 250 mg/kg showed significant reduction when compared to INH
group, but administration of Salvia officinalis L. extract 250 mg/kg
alone and with INH has alleviated gamma-glutamyl transferase comparing to INH
receiving rats. After treatment of rats with INH 50mg/kg, severe tissue
necrosis, and inflammation of central vein in liver and lymphocyte
proliferation were observed; in the experimental group receiving Salvia
officinalis L. extract (250 mg/kg) mild dilution in central vein and
sinusoids in liver were seen. In rats coadministered with Salvia officinalis L. extract 250 mg/kg and INH low sinusoids dilution was indicated. It seems
that Salvia officinalis L. extract exhibited anti-oxidative and
hepatoprotective effects.