TITLE:
The EPHX1 rs1051740 Polymorphism Is Associated with Childhood Acute Lymphoblastic Leukemia in a Korean Population
AUTHORS:
Hee Nam Kim, Nan Young Kim, Li Yu, Il-Kwon Lee, Min-Ho Shin, Hee Jo Baek, Hoon Kook, Hyeoung-Joon Kim
KEYWORDS:
EPHX1, Polymorphism, Association, Childhood ALL
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.5 No.7,
June
27,
2014
ABSTRACT: Microsomal epoxide hydrolase (EPHX1) is involved in the activation and detoxification
of exogenous chemicals. Genetic polymorphisms in EPHX1 have been associated with the development of leukemia. To investigate
an association between single-nucleotide polymorphisms (SNPs) of EPHX1 and risk factors for childhood acute
lymphoblastic leukemia (ALL) in Korean children, we genotyped two SNPs, Tyr113His
(rs1051740) and His139Arg (rs2234922) in 185 childhood ALL cases and 536 healthy
controls. Genotyping for these two SNPs was performed by simplex pyrosequencing
assay and high-resolution melt analysis, respectively. We found that the Tyr113His
genotype was associated with a decreased risk of childhood ALL (odds ratio, OR =
0.64, 95% confidence interval, CI = 0.43 - 0.93; p = 0.02). There was no association
between His139Arg and the combined genotypes
and the risk of childhood ALL. These results suggest that the EPHX1 113TyrHis genotype may protect
against leukemogenesis in childhood.