TITLE:
Antileishmanial Assay and Antimicrobial Activity on Crude Extracts of Melodinus eugeniifolus Barks and Leaves from Malaysia
AUTHORS:
Lu Yao, Khoo Ten-Jin, Wiart Christophe
KEYWORDS:
Antileishmanial Activity, MTT Assay, Antimicrobial Activities, Apocynaceae
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.7,
June
26,
2014
ABSTRACT: Melodinus eugeniifolus, a very rare medical plant which belongs to the family of Apocynaceae, has just been discovered in the Malaysia rain forest. Six different
extracts of Melodinus eugeniifolus (a very rare
medical plant belongs to Apocynaceae) leaves and barks
were screened for the in vitro antileishmanial and antibacterial activities, among the
different extracts tested, the ethanol and hexane extract of barks showed
significant antileishmanial activities with IC50 value of 159.9 μg/ml and 270.3
μg/ml. All the extracts displayed remarkable antibacterial
activity against Staphylococcus aureus, Bacillus cereus and Escherichia coli. Highlights: Melodinus eugeniifolus, a very rare
medical plant from South Asian rain forest which may be a potential drug for
many diseases is first reported its antileishmanial and antimicrobial
activities.