TITLE:
Antidiabetic Drugs in Combination with Hydroxychloroquine Improve Glycemic Control in Alloxan Induced Diabetic Rats
AUTHORS:
Shaheda Zannah, Md. Saiful Islam, A. F. M. Towheedur Rahman, Md. Asaduzzaman, Abdul Alim Al Bari, Yusuf Ali, Gazi Jahirul Islam, A. H. M. Khurshid Alam, Hazrat Ali, Mamunur Rashid
KEYWORDS:
Diabetes Mellitus, Glycemic Control, HCQ, Glibenclamide, Metformin
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.5 No.7,
June
26,
2014
ABSTRACT: Worldwide prevalence of diabetes mellitus has become an issue of great
concern in current decades. This life threatening disease is associated with
worsening of glycemic control and progressive metabolic dysfunctions. Objective:
Current study aimed to investigate the effect of hydroxychloroquine (HCQ) as
an adjunct to glibenclamide or metformin on glycemic control in alloxan induced
diabetic rats. Methods: HCQ was combined separately with two conventional
anti-diabetic drugs; glibenclamide and metformin. At first, alloxan (120 mg/kg)
induced diabetic rats were treated with single dose of metformin (850 mg/70 kg
BW), glibenclamide (10 mg/70 kg BW) and HCQ (300 mg/70 kg BW) intraperitoneally
once daily for two weeks. Then non fixed dose combinations of glibenclamide
(5 mg/70 kg BW) with HCQ (150 mg/70 kg BW) and metformin (425 mg/70 kg BW) with
HCQ (150 mg/70 kg BW) were injected along with those of the three drugs alone
once daily for four weeks. Results: In alloxan induced diabetic rats, glibenclamide,
metformin and their combination therapies reduced blood glucose level
significantly but combination therapies are
the most effective. Glibenclamide or metformin in combination with HCQ also
significantly (P