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Shane, A.L., Cabana, M.D., Vidry, S., Merenstein, D., Hummelen, R., Ellis, C.L., Heimbach, J.T., Hempel, S., Lynch, S.V., Sanders, M.E. and Tancredi, D.J. (2010) Guide to Designing, Conducting, Publishing and Communicating Results of Clinical Studies Involving Probiotic Applications in Human Participants. Gut Microbes, 1, 243-253.
http://dx.doi.org/10.4161/gmic.1.4.12707

has been cited by the following article:

• TITLE: Dietary Intervention with Yoghurt, Synbiotic Yogurt or Traditional Fermented Sobya: Bio-Potency among Male Adolescents Using Five Bio-Markers of Relevance to Colonic Metabolic Activities

  AUTHORS: Laila Hussein, Moustafa Gouda, Mohamed Fouad, Eid Labib, Ranya Bassyouni, Mahmoud Mohammad

  KEYWORDS: Probiotics, Egyptian Male Adolescents, Intestinal Microbiota, Fecal Short Chain Fatty Acids

  JOURNAL NAME: Food and Nutrition Sciences, Vol.5 No.12, June 26, 2014

  ABSTRACT: The objective of the present work is to test the effectiveness of probiotic potency of regular yoghurt, synbiotic yoghurt and traditional fermented Egyptian sobya containing endogenous probiotic strains compared to unfermented rice milk porridge. Methods: The study consisted of 28 male subjects with mean age of 13.9 ± 0.1 years. The subjects were divided into four groups, three groups consumed one of three fermented supplements, while the fourth group served as a control group. Stool and urinary samples were carried out prefeeding and after 3-week nutritional intervention for assessing five indicators of revelance to colonic metabolic activities. The fermented supplements used for evaluation were regular yoghurt, synbiotic yoghurt and traditional fermented sobya; while the fourth group was given unfermented rice milk and served as control. Intestinal permeability was assessed by the urinary lactulose mannitol ratio. Results: The mean fecal total lactobacilli counts increased (P 0.05). Mean fecal short chain fatty acids concentrations (acetic; propionic and butyric) tended to increase following the intervention with synbiotic yogurt or sobya compared to respective pre-intervention values; but the difference didn’t attain significance (0.1>P> 0.05). The 3-week nutritional intervention didn’t impact the activities of the fecal hydrolytic enzymes. Conclusion: Nutritional intervention with regular yoghurt, synbiotic yoghurt or traditional fermented sobya improved the balance of human resident microbiota and other GI tract-associated health parameters to variable degrees.